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KMID : 1101020210460030069
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Journal of Oral Medicine and Pain
2021 Volume.46 No. 3 p.69 ~ p.74
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Pathophysiology of Temporomandibular Joint Arthritis: Review
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Ju Hye-Min
Kim Kyung-Hee
Jeong Sung-Hee
Ahn Yong-Woo
Ok Soo-Min
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Abstract
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As for temporomandibular joint arthritis (TMJ OA), managing the contributing factors at an early stage through accurate diagnosis is necessary to prevent irreversible bone changes. TMJ OA, which is a multi-organ disease caused by various pathophysiological mechanisms, is developed mainly due to mechanical overload. It is a disease characterized by degeneration of articular cartilage and subchondral bone as a low-level inflammatory arthritis condition developed by dysregulation of catabolic and anabolic activity of chondrocytes. Age, mechanical overload sensing of cartilage, chondrocyte apoptosis, catabolic enzymes, inflammatory factors, abnormal remodeling of subchondral bone, and estrogens may be involved in the pathogenesis of arthritis. Therefore, a comprehensive evaluation is needed to diagnose and manage progressive cartilage degeneration, subchondral bone remodeling, and associated symptoms of TMJ OA.
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KEYWORD
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Pathophysiology, Temporomandibular joint, Temporomandibular joint arthritis, Temporomandibular joint disorder
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